BDNF is a member of the neurotrophin family of growth factors that includes NGF, NT-3, and NT-4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level.
BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglion cells. There are many companies available that provide the bdnf elisa kit also.
1 BDNF is expressed in peripheral ganglia and is not confined to neural target planes, raising the possibility that BDNF may have paracrine or even autocrine effects on neurons as well as non-neuronal cells.
Image Source: Google
The active form of the recombinant human BDNF protein (27 kDa) is a dimer formed from two identical subunits of 119 amino acids held together by strong hydrophobic interactions.
Recombinant human protein derived from brain neurotrophic factor (BDNF) is used as an additive in various types of culture media.
Brain-derived neurotrophic factor (BDNF) is a member of the 13.6 kDa (or 27.2 kDa dimer) neurotrophin family. In humans, mice, and pigs, BDNF has an identical amino acid sequence with complete cross-reactivity.
BDNF is important for the development and maintenance of populations of neurons in the central nervous system or cells directly related to them.
BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglion cells.